When printing in Outlook 2007 you may receive the following error Unable to save the printer settings. Make sure the file c:\windows\outlprnt is not missing or write protected. This can be very frustrating, it recently happened to one of my executive customers. What we did to fix this error in Outlook 2007 was to browse to the c:\documents and settings\username\application data\microsoft\outlook folder, (replace username with the user profile of your user.) then we created a word document called Outlprnt.doc and left it blank just saved it so there was a file that existed. Then we closed Outlook 2007 and reopened and could print without seeing the ERROR Unable to save the printer settings. Make sure the file c:\windows\outlprnt is not missing or write protected.
If this does not work try opening the Outlprnt.doc file and put an x in it and save then close Outlook 2007 and try printing again.